disodium [(2R,3S)-3-methyloxiran-2-yl]phosphonate
phosphomycin disodium salt
CAS: 26016-99-9
Molecular Formula: C3H8NaO4P
disodium [(2R,3S)-3-methyloxiran-2-yl]phosphonate - Names and Identifiers
| Name | phosphomycin disodium salt |
| Synonyms | 2S)-1 Fosfomycin sodium phosphomycin disodium Disodium phosphonomycin Fosfomycin disodium salt phosphomycin disodium salt (3-methyloxiran-2-yl)phosphonic acid Sodium ((2S,3R)-3-methyloxiran-2-yl)phosphonate disodium [(2R,3S)-3-methyloxiran-2-yl]phosphonate (1,2-epoxypropyl)-,disodiumsalt(1r,2s)(-)-phosphonicaci [(2R,3S)-3-Methyloxiran-2-yl]phosphonic acid disodium salt disodium keto-[(2R,3S)-3-methyloxiran-2-yl]-dioxido-phosphorane |
| CAS | 26016-99-9 |
| EINECS | 247-409-2 |
| InChI | InChI=1/C3H7O4P.2Na/c1-2-3(7-2)8(4,5)6;;/h2-3H,1H3,(H2,4,5,6);;/q;2*+1/p-2/t2-,3+;;/m0../s1 |
| InChIKey | QZIQJIKUVJMTDG-OTUWWBTESA-L |
disodium [(2R,3S)-3-methyloxiran-2-yl]phosphonate - Physico-chemical Properties
| Molecular Formula | C3H8NaO4P |
| Molar Mass | 162.06 |
| Melting Point | >300°C |
| Boling Point | 342.7°C at 760 mmHg |
| Flash Point | 161°C |
| Water Solubility | Freely soluble in water or aqueous solution |
| Solubility | H2O: 50mg/mL, clear, colorless |
| Vapor Presure | 1.34E-05mmHg at 25°C |
| Appearance | neat |
| Color | White to Off-White |
| BRN | 4604425 |
| Storage Condition | Inert atmosphere,2-8°C |
| MDL | MFCD22741288 |
| Use | For the treatment of infections caused by Staphylococcus aureus, Escherichia coli, Proteus and Shigella |
disodium [(2R,3S)-3-methyloxiran-2-yl]phosphonate - Risk and Safety
| Risk Codes | R11 - Highly Flammable R34 - Causes burns |
| Safety Description | S16 - Keep away from sources of ignition. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| WGK Germany | 2 |
| RTECS | SZ7902000 |
| FLUKA BRAND F CODES | 10-21 |
| HS Code | 29419090 |
disodium [(2R,3S)-3-methyloxiran-2-yl]phosphonate - Reference
| Reference Show more | 1. [IF=4.759] Zhihua Song et al."Synthesis and evaluation of fosfomycin group end-capped packing materials for hydrophilic interaction liquid chromatography."J Chromatogr A. 2021 Oct;1656:462529 |
disodium [(2R,3S)-3-methyloxiran-2-yl]phosphonate - Reference Information
| appearance properties | it is a white crystalline powder at room temperature, which is hygroscopic, easily soluble in water, and exothermic when dissolved. Fosfomycin sodium can be combined with a bacterial cell wall synthase to prevent bacteria from using related substances to synthesize the first step of the cell wall, thereby acting as a bactericidal effect. For Staphylococcus, Streptococcus pneumoniae, Escherichia coli, Neisseria gonorrhoeae, Proteus mirabilis, Typhoid bacillus, Serratia, most Pseudomonas aeruginosa, Streptococcus pyogenes, Streptococcus faecalis, some indole-positive Proteus and certain Klebsiella, Enterobacter bacteria, etc. have antibacterial effects. Fosfomycin sodium is mainly used to treat infections of urinary tract, urinary system, skin and soft tissue, respiratory tract, intestinal tract and other parts caused by sensitive gram-negative bacteria. It can also be combined with other antibiotics to treat severe infections caused by sensitive bacteria such as sepsis, lung, meningeal infection, peritonitis, uterine adnexitis, intrauterine infection, pelvic inflammatory disease, osteomyelitis, etc. It can also be combined with vancomycin to treat methicillin-resistant Staphylococcus aureus (MRSA) infection. |
| pharmacological action | 1. wide antibacterial spectrum, high bioavailability, fast absorption, strong antibacterial power, not affected by diet. It has a killing effect on Gram-positive and negative bacteria, especially on Pseudomonas aeruginosa, Proteus, Salmonella and Staphylococcus and Escherichia coli, which are resistant to various drugs, can show excellent antibacterial activity. For animals, there is no drug resistance and cross-resistance, and the clinical treatment effect is good. 2. Rapid sterilization: This product is a fast fungicide, and its effect is obvious after 1-2 hours. About 25% of E. coli was killed 1 hour after exposure to fosfomycin (12.5 μg/ml), and all died within 4-6 hours. Pseudomonas aeruginosa and Staphylococcus aureus were also all killed at 4 and 8 hours, respectively. 3. Low toxic and side effects, little irritation to the body, no acute toxicity and adverse reactions, and will not increase the burden on the kidneys. 4. Low residue: The elimination time to reach the residue standard in muscles and organs is 48-72 hours. |
| indication | is mainly used for the treatment of acute and chronic intestinal diseases caused by staphylococcus, streptococcus, Escherichia coli, salmonella and other gram-negative bacteria in chickens, ducks and pigs. |
| usage and dosage | for drinking water for livestock and poultry: add 5-10g of this product to every 100kg of water, twice a day for 3 days. For livestock and poultry mixing: 10-15g of this product is added to every 100kg of feed, twice a day for 3 days. |
| combination drug | is used for the treatment of intestinal infection. fosfomycin sodium can be used in combination with β-lactam and aminoglycoside. It can be used in the treatment of respiratory tract and pulmonary infection, and can be used in combination with macrolides and β-lactam. It is used for the treatment of Staphylococcus aureus infection and should be combined with erythromycin and rifampin. For the treatment of severe respiratory infections, sepsis, peritonitis and other increased dosage. It needs to be combined with β-lactam or aminoglycoside. |
| detection index | serial number inspection item export standard CP2000 edition 1 character white crystalline powder odorless, salty white crystalline powder odorless, salty 2 identification is positive reaction is positive reaction 3 specific rotation degree -4.2 ~-5.5 -4.2 ~-5.5 4 heavy metal ≤ 0.0010% 0 ≤.0010% 5 content ≥ 700 μ/mg ≥ 700 μ/mg 6 alkalinity 9.0-10.5 9.0-10.5 7 loss on drying ≤ 1.0% ≤ 1.5% (moisture) 8 solution clarity ≤ 3/4 turbidity standard solution ≤ 1 turbidity standard solution 9 solution color ≤ yellow 1 ≤ yellow 1 10 diol ≤ 0.50% ≤ 0.50% 11 solution clarity shall not meet the requirements (gross point ≤ 8/g, among them, color points ≤ 2/g) 12 tungsten ≤ 0.002%- 13 phosphorus content -16.2-17.9% 14 aseptic compliance regulations compliance regulations 15 heat source/bacterial endotoxin compliance regulations (heat source) compliance regulations (bacterial endotoxin) 16 α-phenethylamine ≤ 0.01% -- 17 methanol residue real number 18 ethanol residue real number The above information is the main detection index of fosfomycin sodium export. |
| precautions | 1. this product is mainly used for pigs, chickens and fish; For other animals, medication should be under the guidance of veterinarians. 2. The combination of fosfomycin and β-lactam, aminoglycosides and macrocyclic acylates has synergistic effect, and can reduce or delay the occurrence of bacterial drug resistance. |
| use | for the treatment of infections caused by staphylococcus aureus, escherichia coli, proteus and dysentery bacillus |
Last Update：2024-04-09 02:00:07
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